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Paludrine & Avloclor Side Effects

Paludrine & Avloclor is a commonly used antimalarial which can be taken to protect against infections of the malaria parasite where it's not become resistant to chloroquine. It's not common for Paludrine Avloclor side effects to occur, but they could be more likely to affect some people than others. It's also possible to make developing side effects much less likely by ensuring that you take it correctly, adjusting how you use it or by taking an alternative antimalarial if you have a condition that could make you more vulnerable to developing Paludrine Avloclor side effects.


Headaches are a common yet mild side effect associated with Paludrine & Avloclor. Mood changes, such as increased anxiety, are very rare.


Gastric side effects are commonly reported and could include an upset stomach, diarrhoea, vomiting, stomach cramps and/or constipation.


Though it is rare, the skin may be affected by this medication. It may cause rashes, psoriasis or itchiness.


It is rare for Paludrine & Avloclor to affect your hearing, but loss of hearing and tinnitus has been reported in a very small number of patients.

Paludrine & Avloclor side effects

Click on the relevant area of the body to find out about how it may be affected by Paludrine & Avloclor

What are the Paludrine Avloclor side effects?

Paludrine & Avloclor can cause side effects, but just like with any other prescription medication they won't affect everyone. The most common Paludrine Avloclor side effects that affect people are luckily mild and could include:

  • Headache
  • Upset stomach
  • Vomiting
  • Diarrhoea
  • Constipation
  • Stomach cramps

The following Paludrine Avloclor side effects are much rarer but they can potentially be serious so seek medical help if you experience any of the below or anything not listed below:

  • Rashes, itchiness or psoriasis
  • Blistering and peeling of the skin in the mouth or nose
  • Discoloration of the mucous membranes in the mouth
  • Over-sensitivity to sunlight
  • Changes in hair colour
  • Hair loss
  • Blurred vision
  • Double vision
  • Loss of hearing
  • Ringing in ears known as tinnitus
  • Reduced number of blood cells
  • Changes in heart function
  • Liver problems
  • Inflammation of the lungs
  • High temperature
  • Feeling of weakness
  • Inflammation of the mouth
  • Nervousness
  • Mood changes
  • Convulsions or fits

Who is most likely to get Paludrine Avloclor side effects?

It’s not recommended that you use Paludrine & Avloclor if you are allergic to proguanil hydrochloride or chloroquine phosphate, the two active ingredients, as taking it could lead to an allergic reaction, which is one of the most serious Paludrine Avloclor side effects.

You should also make sure that you mention any medical conditions you might have to your doctor to ensure that you can use Paludrine & Avloclor safely. Some people might have to take special care when taking Paludrine & Avloclor and these groups include people with epilepsy, those with liver or kidney problems, people with porphyria, those with psoriasis, if you have mysasthenia gravis, and those with a blood problem known as glucose-6-phosphate dehydrogenase deficiency. Although it’s unlikely to be a problem, you should speak to your doctor before using this antimalarial if you are pregnant or breastfeeding.

What medications can enhance the likelihood of Paludrine Avloclor side effects?

Some medications may increase the risk of you developing Paludrine Avloclor side effects, which is why it's important to mention any medications you are taking to the doctor during your doctor's consultation, in particular if you are using the following medicines:

  • Praziquantel (used in the treatment of parasitic infections)
  • Cyclosporin (used after organ transplants and to treat rheumatoid arthritis)
  • Medicines used to prevent convulsions and fits
  • Digoxin (used in the treatment of heart problems)
  • Warfarin (prevents blood clotting)

Other malaria treatments

  • Cimetidine (treats stomach problems)
  • Antacids
  • Amiodarone (controls heart rate)

How to avoid Paludrine Avloclor side effects

Making sure that you only take Paludrine & Avloclor if it’s absolutely right for you will lower your risk of developing Paludrine Avloclor side effects quite substantially. Most of the common Paludrine Avloclor side effects can also be avoided by ensuring that you take the tablets with food.

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