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Evorel Sequi

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  • Evorel® Sequi Theramex pack contains 8 transdermal patches
  • The Evorel® Sequi Theramex transdermal patches come in a pack of 8 and include a sachet
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What is Evorel Sequi?

Evorel Sequi is a hormone replacement therapy preparation. Two types of patches are included in this treatment: Evorel 50 patches, which contain estradiol hemihydrate and norethisterone acetate. These are forms of the main female sex hormones, oestrogen and progesterone.

On the road leading to menopause, women ovaries start to produce less and less oestrogen and this causes oestrogen levels to decline as a result. Deteriorating levels of oestrogen can cause distressing symptoms, such as irregular periods, hot flushes, night sweats, mood swings and vaginal dryness or itching.

Estradiol hemihydrate can be given as a supplement to replace the declining levels of oestrogen in the body and help to make the distressing symptom of menopause more tolerable. This is known as Hormone Replacement Therapy. Hormone Replacement Therapy should be reviewed once a year by your doctor and is usually only required for a short-term relief from menopausal symptoms.

What are the benefits?

Evorel Sequi is applied to the skin and therefore doesn’t have to be taken orally, reducing the risk of side effects. Evorel Sequi is a continuous HRT treatment that contains both estradiol and norethisterone acetate. The estradiol in this treatment is intended to replace oestrogen lost as a result of menopause, while norethisterone acetate - a type of progestogen - works to ensure that the womb remains healthy during treatment in women who have not had a hysterectomy.

The effects of these hormones help to treat symptoms such as vaginal dryness, vaginal itching, mood swings and hot flushes.

How does Evorel Sequi work?

Evorel Sequi is a combination pack, consisting of the two types of patches Evorel Conti and Evorel. Evorel consists of estradiol only and Evorel Conti contains both estradiol and norethisterone acetate. Estradiol helps to replenish natural oestrogen levels, while progestogen helps with womb health. Progestogen only forms part of the treatment during the last two weeks of your cycle; to ensure that hormonal fluctuation patterns aren’t too far removed from what they would normally be.

Who cannot use Evorel Sequi?

Evorel Sequi patches are intended to be used by women between the ages of 40 and 60 who are experiencing menopause symptoms and who haven’t had their womb surgically removed. You may not have been recommended this medication if you are allergic to the ingredients found in these treatments. Similarly you should also not use this medication if you have a history of breast cancer, cancer of the womb, unexplained vaginal bleeding, fibroids in the womb, blood clots, heart attack, blood disorders (porphyrias), angina or liver disease, or if you are are pregnant or breastfeeding.

How do you use it?

The patch should be placed on skin that is clean and dry straight after it has been unwrapped. Evorel Sequi is a sequential combined HRT and so an Evorel 50 patch (consisting of oestrogen) is applied twice weekly for two weeks, with the Evorel Conti patch (oestrogen and progestogen) used on the 15th day and changed twice during the next two weeks.

How can this medicine affect other medicines?

It is important to be completely open and honest about the medicines you’re taking during your online consultation. These include medicines bought without prescription and herbal medicines. Similarly, it is advised that you consult your doctor or pharmacist before taking any new medicines, while taking Evorel Sequi. This is to ensure that the combination is safe.

The following medicines can reduce the amount blood levels and the effect of this medicine:

  • Antiepileptic medicines such as carbamazepine, phenytoin, phenobarbital and primidone
  • Barbiturates such as amobarbital
  • Protease inhibitors for HIV infection such as ritonavir and nelfinavir
  • Rifamycin antibiotics such as rifabutin and rifampicin
  • The herbal remedy St John's wort (Hypericum perforatum)

What are the side effects?

All prescription medications have the potential to cause side effects, however it doesn't mean that they will occur. Side effects that may be experienced by women who use Evorel Sequi are breakthrough bleeding, spotting, breast pain, tenderness and enlargement, vaginal thrush, headache, migraine, anxiety, depression, skin rash, disturbances in liver function, leg cramps, blood clots, weight changes, nausea, irregular brown patches on the skin, abdominal pain, ingestion and PMS symptoms.

Can I buy Evorel Sequi online??

You can buy Evorel Sequi online from euroClinix, however, to ensure that you can use your medication safely, we ask all our patients complete a quick and confidential online consultation form. This will be checked by one of our doctors and if you are approved to use this medication, a prescription will be issued and your treatment will be shipped directly to you from our pharmacy.

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Medically reviewed by Dr. Plauto Filho Written by our editorial team Last reviewed 13-03-2024
Evorel Sequi information
Product nameEvorel Sequi
Active ingredient(s)Estradiol and Norethisterone Acetate
ManufacturerJanssen Cilag
Trustpilot rating4.6/5
Trustpilot reviews5
AvailabilityOut of stock
DescriptionEvorel Sequi is a form of hormone replacement that provides relief from the symptoms of menopause
ExemptionSubject to medical prescription
Available dosage50mcg
ApplicationWomen over 18 looking to relieve the symptoms of menopause
UsageApply relevant patch below the waist 2 times per week
Drug classHRT, sequential combined
Alcohol consumptionNo known influence
When breastfeedingCaution is recommended, ask your doctor and read the leaflet thoroughly for each treatment
When pregnantNot recommended, ask your doctor for alternatives
Evorel Sequi reviews
Evorel® Sequi Theramex pack contains 8 transdermal patches Excellent 4.6 5 patients have reviewed Evorel Sequi on Trustpilot

Further reading

The most common causes of painful sex

The most common causes of painful sex

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Treatment For Vaginal Dryness: How To Get Rid Of It Post-Menopause

Treatment For Vaginal Dryness: How To Get Rid Of It Post-...

Reviewed by Dr. Caroline Fontana
Signs that you should get hormone replacement therapy (HRT)

Signs that you should get hormone replacement therapy (HRT)

Reviewed by Dr. Caroline Fontana
What is the best hormone replacement therapy for menopause?

What is the best hormone replacement therapy for menopause?

Reviewed by Dr. Caroline Fontana
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