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  • Pack of 84 Premique Low Dose 0.3mg/1.5mg modified-release tablets
  • Box of Premique conjugated estrogens and medroxyprogesterone acetate tablets with blister packs
  • Front and rear view of Premique 0.3mg/1.5mg tablet blister packs
  • Box of Premique treatment with patient leaflet
4.8 21 patient review(s) review
3 months (84 tablets) (£24.99)
£24.99 (Including prescription and delivery)
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Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.


4.8 Excellent

21 patient review(s)

Medically reviewed by Dr. Sarah Donald MRCGP DFSRH DPD DRCOG Written by our editorial team
Last reviewed 05 Apr 2021

What are the benefits?

When you start your menopause, your levels of oestrogen decrease. This can lead to a number of symptoms, including hot flushes, night sweats and vaginal dryness. Premique and Premique Low Dose are effective hormonal replacement therapy treatments that help to relieve the symptoms of the menopause. This treatment can also work to slow down the development of osteoporosis, which can occur after the menopause if other treatment has proved unsuccessful.

How does Premique work?

As the menopause approaches, a woman starts to produce less oestrogen, resulting in a drop of oestrogen blood levels. As a result, the decrease in oestrogen levels produces a number of uncomfortable menopausal symptoms. Premique is a period-free HRT, which means that you will not experience a monthly bleed while on this treatment.

Premique and Premique Low Dose contain two active ingredients, including conjugated oestrogens, which work as a supplement for the lack of oestrogen levels, helping to reduce menopausal symptoms. The second ingredient, medroxprogesterone acetate works as a progestogen. For women who have not had a hysterectomy, the increase of oestrogen levels can stimulate the growth of the womb lining, potentially causing endometrial cancer if the womb growth is unchallenged. The inclusion of progesterone is included to counteract the effects of oestrogen on the womb lining, thus reducing the risk of cancer.

Who cannot use Premique?

Premique can be used when you start to experience menopausal symptoms, which for most women is between the ages of 40-60, however this treatment ideally is not recommended for use after your mid fifties. If you are allergic to any of the ingredients in this medication then it is highly recommended that you don’t take this medication. Likewise if you are currently being treated for or have a history of breast cancer, cancer of the lining of the womb or oestrogen-dependent cancer, you will not be prescribed this treatment. Other contra-indications include a history of blood clots, stroke, heart attack, angina, liver disease or problems with the function of the liver; unexplained vaginal bleeding; pregnancy or thinking about becoming pregnant; breastfeeding; and a history of porpohyrias and galactose intolerance.

How do you take Premique?

Premique is usually prescribed in the lowest effective dose for the shortest duration in a 28-day pack. For both HRT dosages, it is advised that you take one tablet at the same time everyday, with no breaks between packs. If you are not currently taking another HRT or taking another period-free HRT, you can start your first pack of Premique at any time. If you are changing from an HRT medication that still enables you to have a monthly bleed, it is generally recommended that you start this HRT after you have finished the course of your previous therapy.

It is important that you take this medication as prescribed by your doctor. If you forget to take a tablet you should take it as soon as possible. However, if the missed pill is more than 12 hours late, it is recommended that you skip the dose you missed and continue to take the next dose at the usual time. Do not double dose to make up for the missed pill.

How can this medicine affect other medicines?

It is of utmost importance to be completely open and honest when discussing the medicines that you're taking during your online consultation. This includes medicines bought without prescription and herbal medicines. Similarly, it is advised that you consult your doctor or pharmacist before taking any new medicines while taking this one. Your doctors or local pharmacy will be able to advise you on which medicines will have a negative affect on your body when collaborated with Premique.

  • Antiepileptic medicines such as carbamazepine, phenytoin, phenobarbital and primidone
  • Barbiturates such as amobarbital
  • Nevirapine or efavirenz for HIV infection
  • Protease inhibitors for HIV infection such as ritonavir and nelfinavir
  • Rifamycin antibiotics such as rifabutin and rifampicin
  • The herbal remedy St John's wort (Hypericum perforatum)

Does Premique have any side effects?

Like most medications Premique may cause side effects, although not every person using this medication will develop them. Side effects with this medication include, but are not limited to, breast pain, tenderness and nipple discharge; muscle and joint ache; weight changes and breakthrough vaginal bleeding or spotting. It is also possible that you may experience more serious side effects, such as changes in triglyceride levels and mood; problems with the heart or kidneys; blood clots and migraines. If you are concerned about side effects, you should contact your doctor or a health professional for advice. It is important to always read the supplied Patient Information Leaflet before commencing a course of treatment.

How can I buy Premique?

Both Premique and Premique Low Dose HRT are available to buy at euroClinix. To place your order, simply complete an online confidential consultation form. A qualified doctor, who after assessing your consultation and confirming that this medication is suitable, will issue a prescription for this treatment. Our registered pharmacy will then dispense this treatment and dispatch it to you using our free next day delivery service.

Treatment Information
Treatment Information
Product Name: Premique
Active Ingredient(s): Medroxyprogesterone Acetate and conjugated oestrogens
Manufacturer: Pfizer
Description: Premique is a hormone replacement that offers relief from the symptoms of menopause by replenishing depleted hormone levels
Exemption: Subject to medical prescription
Administration: Oral
Presentation: Tablets
Available Dosage: 300mcg
Application: Women over 18 looking to relieve the symptoms of menopause
Posology: Take 1 tablet per day
Drug class: HRT, continuous combined
Alcohol consumption: 0
When breastfeeding: Not recommended, ask your doctor for alternatives
When pregnant: Not recommended, ask your doctor for alternatives
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Product ratings
Excellent 4.8 21 patients have reviewed Premique
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Current reviews for the treatment Premique

Rated with 4.8 based on 21 independent customer reviews (See all euroClinix reviews).

  • Excellent Product Review:: Very quick and efficient, Web site is easy to use. 01 Sep
  • Great Product Review:: It is the same medication as I used before it was stopped.I have not yet started... 30 Aug
  • Excellent Product Review:: I could not live a normal life without it. No more hot flushes. Yippee! 25 Aug
  • Excellent Product Review:: Life changing ..! 18 Apr
  • Excellent Product Review:: I have had only two tablets so far so I can't really tell. I feel optimistic tho... 13 Mar