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Mysimba is a prescription weight-loss treatment. Each tablet contains two active ingredients; 8mg of naltrexone hydrochloride and 90mg of bupropion hydrochloride. It was approved for weight loss treatment in Europe in April 2015.
It is available for those over the age of 18 who have a body mass index (BMI) of 30 or more. Alternatively, if you have a BMI of 27 to 30 and suffer from weight-related conditions, like high cholesterol, high blood pressure or type 2 diabetes, you can also be prescribed Mysimba.
Mysimba should be taken with a reduced-calorie diet and increased exercise to see the full effects.
The active ingredients in Mysimba (bupropion and naltrexone) affect the part of your brain that controls your appetite and energy balance. Their combined effect reduces your appetite, food cravings and the pleasure associated with eating food.
This means you eat less and consume fewer calories, which will ultimately help you lose weight.
How Mysimba works | |
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The medicine Two drugs work together to support your weight loss efforts |
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Brain changes Affects your brain's reward system and hunger signals. |
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Less hungry Reduces cravings and makes it easier to eat less |
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Weight loss Helps you lose weight when combined with diet and exercise |
It is still important to have a healthy diet whilst taking Mysimba to see the full effects. The medicine will help your appetite, but you will need to choose the right foods. You will also need to do regular physical activity to help burn calories as well as stay fit and healthy.
Building these healthy habits also sets you up for long-term success in managing your weight and staying healthy when you eventually stop taking Mysimba.
Mysimba tablets come in a prolonged-release form, meaning that the effects are released into the body gradually over several hours. So, you will feel the effects of the medicine soon after taking it.
However, it will take a few weeks for you to see the full effects and start losing weight. You should expect to lose at least 5% of your original body weight after 16 weeks of using Mysimba alongside a healthy diet and exercise regime.
Mysimba has several benefits when it comes to weight loss.
These factors may help you choose a weight loss treatment that’s right for you.
You take Mysimba tablets daily. You start by taking one tablet once daily. You gradually increase the dose each week for 4 weeks until you reach the maximum dose of 4 tablets daily.
Week 1 |
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Week 2 |
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Week 3 |
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Week 4 and onwards |
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Do not take Mysimba too close to bedtime as this may affect your sleep.
You should swallow each tablet whole. You may take tablets with a glass of water if needed. Do not cut, chew or crush them. You should take your tablets with food.
You will need to take Mysimba for a minimum of 16 weeks to see the full effects. You will need to check in with your doctor after these first 16 weeks to monitor your progress.
If you have not lost at least 5% of your starting weight after 16 weeks, you should discontinue treatment as it might not be right for you.
You can then continue taking Mysimba until you reach a healthy BMI.
Do not stop taking Mysimba without consulting your doctor first.
If you miss a dose, skip it and take the next dose at your regular time. Do not take a double dose to make up for it. Taking too many tablets could put you at a greater risk of side effects.
To see the full effects of Mysimba, it is essential that you modify your diet and lifestyle.
To help you lose weight on Mysimba, it’s important to make healthy food choices.
You will need to reduce how many calories you consume daily. You can use our calorie calculator below to find out how many calories you need to consume a day to lose weight.
You should also prioritise healthy foods as well as the amount you eat. Prioritise lean proteins, fruits, vegetables and good carbs. You should also avoid processed foods that are high in sugar or fats like cakes, sweets and fast food.
Alongside modifying your eating habits, you should also increase the amount of physical activity you do. This will help burn calories, boost your metabolism and improve your physical health in general.
You could do cardio (e.g. running), lift weights, try yoga, try pilates or even just go on walks. Start exercising a little and often, and gradually increase the intensity once you build your stamina.
Clinical trials have been conducted to measure the effectiveness of Mysimba for weight loss compared to a placebo (an inactive drug). These trials measured the percentage of weight lost over 26 to 56 weeks of treatment.
Three studies showed that the average weight loss in patients taking Mysimba was around 3.7% to 5.7%, whereas those taking the placebo had an average weight loss of 1.3% to 1.9%.
These studies also found that the overall weight loss in patients taking Mysimba was 8.1% compared to only 4.9% with the placebo after 56 weeks. In addition, 30% of the participants who took Mysimba in this study achieved a 10% weight loss.
Mysimba is suitable for people who are above a certain body mass index (BMI). This is a medical measure of obesity based on your height and weight.
Mysimba is suitable for people who have a BMI of 30 or above.
You are also suitable for Mysimba if you have a BMI of 27 or above and have at least one weight-related condition. This includes:
You can calculate your BMI at euroClinix for free using our free tool below.
If you are not sure if you are able to take it, please consult your doctor.
Mysimba may not be suitable for everyone. This includes those who:
If you fall under one of these categories, you cannot take Mysimba because you are at high risk of side effects.
If you have another medical condition, you should always ask a healthcare professional before starting Mysimba. It may be safe for you to take, but you may need to be closely monitored by your doctor.
Consult your doctor if you:
You may also be at a greater risk of side effects, and your doctor will need to assess whether it is safe for you to take.
Our doctors at euroClinix will be able to know if it’s suitable for you when you complete our consultation form about your medical history before prescribing you the medication.
As with all medications, there is a chance you may experience some side effects.
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These side effects are usually mild and go away once you have finished treatment.
Mild side effects can also be managed with simple lifestyle tips. Increasing the amount of fibre you eat or taking gentle laxatives can help with constipation. Staying hydrated will also help if you experience vomiting.
Uncommon side effects can affect up to 1 in every 100 people who take this medicine.
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Rare side effects of Mysimba occur in up to 1 in every 10,000 people who take it. So, it is very unlikely you will experience any rare side effects. However, it’s important to know what to expect should you experience any.
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If your symptoms don’t go away or you experience more severe side effects, consult your doctor as soon as possible.
For a full list of side effects, please refer to the patient information leaflet.
Mysimba may interfere with other medicines you are taking.
Do not take Mysimba with:
You should also talk to your doctor if you take any of the following medicines, as you may be more at risk of side effects:
For a full list of interactions, refer to the patient information leaflet.
Category | Status | Advice |
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Alcohol | Consult your doctor | Taking Mysimba with alcohol may cause side effects, so your doctor may advise you to not drink any whilst taking it. If you struggle with alcohol misuse and/or are trying to drink less, consult your doctor. |
Pregnancy | Unsafe | It is unsafe to take Mysimba while pregnant as the risks to humans are not known. |
Breastfeeding | Unsafe | Traces of Mysimba can pass into breast milk, but it is not known what the potential risk is to humans. So, it is advised that you do not take it if you are breastfeeding. |
Driving | Caution | Mysimba can cause side effects like drowsiness/dizziness and, in rare cases, seizures. Do not drive until you know how the medicine affects you |
This medicine does not have any specific storage requirements. However, you should keep it out of sight and reach of children.
You should also not use it past the expiry date. You can see the expiry date on the medicine carton after EXP. The date refers to the last day of the month.
Do not discard expired medicines in general waste or in the toilet. This is bad for the environment. Take your expired medicines to your local pharmacy to dispose.
No, Mysimba is not available over the counter. It is only available via prescription from a registered doctor. This is so the doctor can ensure the medicine is safe for you to use. However, if you cannot get to your GP, you can get a prescription from an online healthcare provider such as euroClinix.
Ordering Mysimba through euroClinix is simple and secure. Follow these steps:
euroClinix offers ongoing support for any questions. Privacy and security are guaranteed through compliance with the relevant regulatory standards and the use of encrypted transactions.
euroClinix is a trusted online clinic that offers services in several European countries. All consultations and prescriptions are handled by our UK-registered doctors.
The process is convenient with online consultations and discreet home delivery. Our friendly customer service team is always happy to assist with any questions related to our services.
The euroClinix platform is user-friendly for managing prescriptions and reorders securely.
Choosing euroClinix ensures a trusted, professional, and supportive service for weight loss.
The price of Mysimba will depend on the healthcare provider. At euroClinix, we have competitive prices that include free delivery and consultation.
There are many factors to consider when determining which weight loss drug is best for you. Below are all the alternative treatment options available and how they compare to Mysimba.
There are several prescription weight loss tablets available as well as Mysimba.
You can also use weight loss injections.
Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.
Group of medication | Opioid antagonists/ NDRIs (norepinephrine-dopamine reuptake inhibitors) |
Used for | Weight loss |
Active ingredient(s) | Naltrexone with bupropion |
Works by | Targets brain activity responsible for appetite and energy use |
Effective within | 4 weeks |
Suitable for | Adults with a BMI of 30 or above, or 27 and above with a weight-related condition (e.g. type 2 diabetes) |
Available as | Prolonged-release tablets |
Available strength | 8mg (naltrexone) /90mg (bupropion) |
Dosage instructions | Starting dose of one tablet once daily for one week, increase by one tablet each week until reaching 4 tablets per day in week 4. |
Manufacturer | Orexigen Therapeutics |
Generic available | No |
Storage | Store at room temperature below 30°C. Keep out of sight and reach of children. |
Prescription required | Yes - included with our free online consultation. |
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