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Home / Weight Loss / Mounjaro injection pen

Mounjaro injection pen

All you need to know about the new Mounjaro weight loss injection

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What is Mounjaro?

Mounjaro is a weight loss injection that has been recently approved by the European Medicines Agency (EMA). It has been clinically proven to help adults lose weight gradually when used together with a low-calorie diet and physical activity.

Mounjaro pen

The EMA has also approved Mounjaro to treat adults who have type 2 diabetes when used together with diet and physical activity. It can be used on its own or as an ‘add-on’ to other diabetes medicines.

How does Mounjaro work?

Mounjaro works by reducing your appetite, so you don’t eat as much and therefore consume fewer calories. It also slows down the emptying of the stomach, keeping you fuller for longer. However, this effect reduces over time.

Mounjaro contains the active ingredient, Tirzepatide which activates two different receptors known as GLP-1 and GIP. These hormones are involved in regulating our blood sugar levels and appetite.

Most weight loss injections are only GLP-1 receptor agonists. However, Mounjaro’s dual effects cause more weight loss than weight loss medicines that work on GLP-1 alone.

It also helps lower your blood sugar levels by enhancing insulin secretion and improving the body’s response to insulin.

Who can use it?

Mounjaro is now approved for use in people who are obese with a body mass index (BMI) of 30 kg/m2 or more. It may also be approved for adults who are overweight (BMI between 27 and 30 kg/m2) and have weight-related health problems such as:

  • prediabetes
  • type 2 diabetes
  • high blood pressure
  • high cholesterol
  • heart disease (including a heart attack, stroke, coronary artery disease) 
  • obstructive sleep apnoea
  • PCOS (polycystic ovarian syndrome)
  • osteoarthritis or gout
  • chronic back pain
  • fatty liver disease
  • gallbladder disease

Although Mounjaro can be used to treat type 2 diabetes in adults, at euroClinix we will only offer this treatment for weight loss once it becomes available.

Who cannot use it?

You cannot use this medicine if:

  • you are allergic to Tirzepatide or any other ingredients in Mounjaro
  • you are pregnant, planning to become pregnant or breastfeeding
  • you have a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

You must inform your doctor if you:

  • have issues with your pancreas, liver, kidneys, or gallbladder
  • have severe stomach problems (including food remaining in your stomach for longer than normal or digestive trouble)
  • have a history of diabetic retinopathy
  • use any other diabetes treatments such as a sulphonylurea or insulin
  • have heart problems (especially involving your heart rate or heart failure)

How do I use Tirzepatide for weight loss?

There are 3 different types of Tirzepatide injection pens for weight loss.

Mounjaro KwikPen

This comes as a pre-filled injection pen that contains 4 doses of the medicine. This should be injected once a week.

Image of the Mounjaro KwikPen parts

Select a day of the week that suits you best for taking this medicine and stick to that same day every week. It’s possible to switch the day you take your dose if you need, as long as you make sure there's at least a 3-day (72-hour) gap between doses.

Select where you'll inject the medicine:

  • You can inject this medicine into your stomach, thighs, or the back of your upper arms.
  • If injecting it into the back of your upper arm, another person should give you the injection.
  • Change your injection site each week.
choose your injection site

Inspect the pen:

  • Check for any signs of damage, and if you find any, do not use it.
  • Check the solution - Mounjaro should be colourless to slightly yellow.
  • Check the label to ensure you have the right medicine and dose.
choose your injection site

Pull the pen cap off and wipe the red inner seal with a swab.

Take a new pen needle and pull off the paper tab.

pull off the cap

Screw the needle (with the cap still on) onto the pen and twist it on until it is firmly attached.

Remove the outer needle shield and keep it aside to use again later. Then pull off the inner needle shield and throw this away.

place and unlock

To prime the KiwkPen, turn the dose knob until you hear 2 clicks and the extended line is shown in the dose window.

Priming the pen removes air from the cartridge and ensures the pen is working correctly.

place and hold

Hold your pen upright with the needle pointing upwards and tap the cartridge holder gently.

Release some medicine into the air by pushing the dose knob in until it stops, then slowly count to 5 while still holding it. Check that the ‘0’ icon appears in the dose window.

pull off the cap

To inject Mounjaro:

Turn the dose knob until a ‘1’ icon appears in the dose window.

Insert the needle into your skin and push the dose knob in until it stops, then slowly count to 5 while still holding the dose knob.

Before removing the needle, make sure the ‘0’ icon appears in the dose window.

Then, pull the needle out of your skin.

place and unlock

Place the outer needle shield back onto the needle, then unscrew this and discard it into a sharps container.

Put the pen cap back onto the pen and store it appropriately.

place and hold

Mounjaro single-dose pen

This pen contains a single dose of the medication and is intended for one-time use.

Image of the Mounjaro single-dose pen parts

Here are 4 easy steps to follow to use the pen correctly:

1. Choose your injection site

  • This medicine can be injected into your stomach, thighs, or the back of your upper arms.
  • Rotate your injection site weekly.
choose your injection site

2. Pull off the grey base cap

  • Make sure your pen is locked.
  • Pull the grey base cap off and throw it away.
choose your injection site

3. Place the base on your skin

  • Place the clear base flat against your skin at the injection site.
  • Unlock the pen by turning the lock ring.
pull off the cap

4. Inject the medicine

  • Press and hold the purple injection button for up to 10 seconds.
  • You will hear 2 clicks
    • First click = injection started
    • Second click = injection is complete
place and unlock

Mounjaro single-dose vial

This form of the medication requires you to draw up the solution yourself for injection. Please note, the needle and syringe recommended by your healthcare provider may look different to the one pictured below.

Image of the Mounjaro single-dose vial parts

To prepare the needle for injection, follow the instructions below:

Step 1:

Remove the plastic cap and wipe the rubber stopper inside with an alcohol swab.

choose your injection site

Step 2:

Remove the outer wrapping from the syringe and needle. If the needle is already attached to the syringe, skip to step 4.

choose your injection site

Step 3:

Place the needle onto the syringe and screw it on until it is firmly attached.

pull off the cap

Step 4:

Remove the needle shield by pulling it off.

Hold the syringe with the needle facing upwards. Then, pull down on the plunger to draw air into the syringe. Do this until the plunger tip reaches the line indicating 0.5 mL.

place and unlock

Step 5:

Push the needle through the rubber stopper of the vial.

Then, push the plunger all the way in to put air into the vial.

place and hold

Step 6:

Turn the vial and syringe upside down. Ensure that the tip of the needle is in the liquid and slowly pull the plunger down until the plunger tip is past the 0.5 mL line.

If there are air bubbles, lightly tap the syringe to let these rise to the top.

pull off the cap

Step 7:

Slowly push the plunger up until the plunger tip reaches the 0.5 mL line.

Then pull the syringe out.

place and unlock

To inject Mounjaro after preparing the needle, follow the instructions below:

Step 8:

Choose your injection site (stomach, thighs, the back of the upper arms).

choose your injection site

Step 9:

Insert the needle into your skin and push down on the plunger to inject your dose.

Keep the needle inside your skin for 5 seconds to ensure you get the full dose.

choose your injection site

Step 10:

Pull the needle out of your skin.

  • If you bleed after the injection, press the injection site with a piece of gauze or an alcohol swab.
pull off the cap

What dose should I use?

Mounjaro comes in different doses, so you and your doctor can decide on the right one for you. You will start with the 2.5mg dose, injected once weekly for 4 weeks. After 4 weeks, your dose will increase to 5mg. Your dose will be gradually increased over a few months, depending on how well the medication works for you and if you experience any side effects.

Mounjaro dosage schedule

Mounjaro is available in 6 different strengths, including 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg and 15mg pens. The maximum dose of Mounjaro is 15mg.

What happens if I miss a dose?

If you forget to take your dose of Mounjaro don’t worry. Simply, take the missed dose as soon as possible within 4 days (96 hours) after the missed dose. If it has been longer than 4 days, skip the missed dose and take your next dose on the day you are scheduled to take it. Do not take 2 doses of Mounjaro within 3 days of each other.

If you have missed a dose, speak to your doctor first before changing your dosing regime.

How do I store Mounjaro?

It's important to store Mounjaro properly to make sure the medication remains effective.

Dosage form Storage Disposal
KwikPen

Store unused pens in the refrigerator between 2°C to 8°C.

Unused pens may be used until the expiry date printed on the label if it has been kept in the refrigerator.

Used pens can be stored at room temperature (up to 30ºC) for up to 30 days. After this, the pen must be thrown away.

After all 4 doses have been administered, throw away the pen in a sharps disposal container.

Single dose pen

Store this pen in the refrigerator between 2°C to 8°C.

You may store your pen at room temperature (up to 30°C) for up to 21 days.

Put your used pen in a sharps disposal container right away after use.

Vial

Store all unopened vials in the refrigerator between 2°C to 8°C.

You may store the unopened vial at room temperature (up to 30°C) for up to 21 days.

Throw away all opened vials after using them, even if there is still medicine left in the vial.

Put your used needle and syringe in a sharps disposal container straight after use.

All forms of Mounjaro must be stored in the original carton to protect it from light. Do not freeze Mounjaro or use it if it has been frozen. Before using your pen, always check to ensure it's not frozen.

Pens, vials, needles and syringes must not be thrown away in the household trash.

How much weight can I lose on Mounjaro?

The results from a study Trusted source The New England Journal of Medicine Peer-reviewed Journals Medical Research and Review Go to source on the effects of Mounjaro over 72 weeks showed the following percentage weight changes:

  • -15% in patients taking 5mg of Tirzepatide
  • -19.5% in patients taking 10mg of Tirzepatide
  • -20.9% in patients taking 15mg of Tirzepatide
  • -3.1% in patients taking the placebo (inactive drug)
Percentage change in body weight at 72 weeks

What are Mounjaro's side effects?

As with any other medication, there is a risk of experiencing side effects while taking this medicine. The common side effects of Mounjaro are listed in the table below.

Very common
(may affect more than 1 in 10 people)
  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
Common
(may affect up to 1 in 10 people)
  • Low blood pressure
  • Dizziness
  • Feeling less hungry
  • Stomach pain or bloating
  • Indigestion, acid reflux, heartburn
  • Gas, burping, bloating

Side effects such as nausea, vomiting and diarrhoea usually occur when the dose of Mounjaro is increased and go away over time.

Rare side effects

Mounjaro may cause uncommon but serious side effects, including:

  • an inflamed pancreas (pancreatitis)
  • low blood sugar (hypoglycemia)
  • serious allergic reactions (symptoms include swelling of the face, lips, tongue or throat, difficulty breathing, severe rash, fainting, and a rapid heartbeat)
  • changes in vision

For a full list of side effects, please refer to the patient information leaflet (PIL) for a complete list.

Talk to a healthcare professional about any side effects that worry you, especially if they don’t resolve. If you experience any rare side effects, contact your healthcare provider straight away.

Are there any medicine interactions?

One of the ways Mounjaro works is by slowing down how quickly your stomach empties. This can affect how well other oral medications are absorbed into your body. Make sure to inform your doctor about any prescription drugs, over-the-counter medications, vitamins, or herbal supplements you're taking.

Mounjaro may interact with or affect:

  • other diabetes medicines (such as insulin or sulphonylureas)
  • other GLP-1 receptor agonists
  • medicines like Warfarin and Digoxin

This medicine can make oral hormonal contraceptives less effective. If you're using an oral hormonal contraceptive, ask your doctor about switching to a different contraceptive. It is also recommended that you use condoms for four weeks after starting Mounjaro and for 4 weeks after any dose increase.

How does Mounjaro compare to alternatives?

Tirzepatide is different from other weight loss injections as it works on two different hormonal receptors, GLP-1 and GIP. Most weight loss injections only work on GLP-1 receptors.

Mounjaro Saxenda Wegovy Trulicity*
Active ingredient Tirzepatide Liraglutide Semaglutide Dulaglutide
Works on GLP-1 & GIP GLP-1 only GLP-1 only GLP-1 only
Dosage frequency Once weekly Once daily Once weekly Once weekly
Licensed for Weight loss & type 2 diabetes Weight loss Weight loss Type 2 diabetes
Other brand names Zepbound (in the U.S.) Victoza (to treat diabetes type 2) Ozempic (type 2 diabetes treatment) -

*Not available as a treatment for weight loss.

When will it become available?

Mounjaro is slowly being rolled out across Europe and will become available shortly if the manufacturer decides to launch. To be notified when this happens, register your email below.

There are, however, other effective weight loss injections currently available, including Saxenda and Wegovy.

Additionally, alternative weight loss medications (in tablet form) such as Mysimba and Xenical are available.

Please note, in order to purchase any prescription weight loss medicines, you will need to complete an online medical consultation which will be reviewed by one of our registered doctors.

If approved, the medication will be sent to you with prompt delivery.

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Medically reviewed by Dr. Caroline Fontana Written by our editorial team Last reviewed 01-04-2024
Mounjaro injection pen information
Product name Mounjaro, Zepbound
Active ingredient(s) Tirzepatide
Manufacturer Eli Lilly and Company
Trustpilot rating -
Trustpilot reviews -
Availability Out of stock
Description A once-weekly weight loss injection
Exemption Subject to medical prescription
Administration Subcutaneous injection
Presentation Injection
Available dosage 2.5mg, 5mg, 7.5mg, 10mg, 12.5mg, 15mg
Application Adults with a BMI of 30 or above, or 27 and above with another weight-related health condition
Posology Consult patient leaflet
Drug class GIP and GLP-1 agonist
Alcohol consumption No interaction
When pregnant/breastfeeding Not permitted

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