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  • Zyban 150mg bupropion hydrochloride prolonged-release 60 tablets
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What is Zyban?

Zyban, also available as the generic* Bupropion, is a treatment for those struggling to quit smoking. You will find a course of Zyban reduces the withdrawal symptoms that make smoking cessation so hard - symptoms include irritability, cravings, mood swings, and headaches.

Other conditions Zyban is prescribed to treat include major depressive disorder (MDD), attention deficit hyperactivity disorder (ADHD) and bipolar disorder. The latter two are off-label prescriptions.

Currently, euroClinix only offers Zyban for smoking cessation. You should contact your GP if you think you need this treatment for another condition.

*A generic medication contains the same active ingredients as a branded equivalent - the only difference is its price.

How does it work?

We all know what makes smoking so addictive - nicotine. Nicotine activates dopamine production in your brain. Dopamine is a hormone that is naturally produced during pleasurable and successful moments in your life. For example, if you complete a difficult task at work, go for a run or listen to music.

In this way, nicotine mimics accomplishments, essentially training your brain into thinking smoking is a beneficial behaviour. The reinforcement of dopamine makes cigarettes very addictive and difficult to quit.

Initially, when you stop smoking, you will experience a loss of dopamine - this is what leads to withdrawal symptoms. In particular, cravings are prevalent at first, as your body desires a dopamine hit.

The effect bupropion has on smoking was first discovered in patients suffering from depression. It was noted that as they took medication containing the active ingredient bupropion hydrochloride, their desire to smoke and number of cigarettes smoked decreased.

As an antidepressant, it is believed that bupropion hydrochloride encourages dopamine release - making nicotine less important to the body. Essentially, Zyban works as a cigarette replacement, but with a lower intensity, so it is easier to quit permanently.

Similarly, euroClinix also offers the medication Champix, which contains varenicline. Champix also mimics the effects of nicotine, allowing you to quit more easily.

How do I take it?

Remember - always follow the advice of a healthcare professional when starting any new medication. You can also consult the patient information leaflet (PIL) for more detailed instructions.

You should start taking this medication while smoking for one to two weeks.

Depending on how many weeks it has been since you started a course of Zyban, will affect how many tablets you should take.

If you are under 65, from days one to three, take one 150mg prolonged-release tablet daily. For the following days, four to six, you should take two tablets, with an eight-hour break between doses.

From day number seven, you should continue to take two tablets daily. On any day of week two you should stop smoking.

For the third week and beyond, you should continue to take two tablets every day. If you get to week seven and you still feel a strong desire to smoke or are smoking, you should inform your doctor. You may need another form of treatment to help you quit.

If you are over 65, you do not increase your dose. Take one 150mg tablet once daily for the entire treatment course.

If you feel as though you are no longer addicted to smoking at any point during the course, do not stop taking Zyban. Otherwise, the urge to resume smoking may return.

Do not take more than the recommended dosage of Zyban, even if you miss a dose. Simply, continue with the next dose as normal. Overuse of this medication will not make it any more effective and will increase the risk of dangerous side effects occurring.

What are the possible side effects of Zyban?

All medications pose a risk of side effects. It is important to report any reactions to your doctor - this includes side effects not listed below or in the patient information leaflet.

For a complete list, please consult the PIL.

The most commonly reported side effects of Zyban include:

  • Abdominal pain
  • Anxiety
  • Problems concentrating
  • Constipation
  • Dizziness
  • Dry mouth
  • Fever
  • Gastrointestinal disorder
  • Headache
  • Hyperhidrosis
  • Hypersensitivity
  • Insomnia (if taken in the evenings)
  • Nausea
  • Vomiting
  • Skin reactions
  • Altered taste
  • Tremors

Another possible but potentially serious side effect of Zyban is depression. If you experience persistent low mood as well as any depressive or suicidal thoughts, please consult your doctor as soon as possible.

You should also know the signs of an allergic reaction - these include skin reactions, difficulty breathing and swelling of the face and mouth. A full list of ingredients is contained in the PIL. If you have an existing allergy, you should inform the doctor before taking Zyban. When ordering from euroClinix, you can notify our medical staff during the online consultation.

Who can use it?

Existing medical conditions and the use of certain medications can make Zyban risky to take. If any of the factors listed below apply to you, it is advisable to consult with a doctor to find another, more appropriate treatment.

  • you are allergic to any of the medication’s ingredients*
  • you are already taking medicine containing bupropion
  • you suffer from seizures or have a history of epilepsy
  • you have a tumor affecting your central nervous system (CNS)
  • you are a recovering alcoholic
  • you are taking medication that increases the risk of seizures
  • you have a history of eating disorders
  • you have severe hepatic cirrhosis (liver disease)
  • you are taking monoamine oxidase inhibitors (MAOIs)
  • you have a history of bipolar disorder

*Ingredients are included in the patient information leaflet.

What precautions should I take?

Do not take more than the recommended dose of Zyban - taking more of this medication will not make it any more effective.

If you have any risk factors that may increase the chance of seizures occurring, for example, history of head injury, alcohol abuse, the use of stimulants and insulin, you should inform your doctor.

As Zyban is also prescribed as an antidepressant, it can affect mood. You should report any emotional changes to your doctor.

If you are pregnant, breastfeeding or planning to conceive, speak to your doctor before starting a course of Zyban.

Can I buy Zyban online?

euroClinix offers a discreet, online pharmacy and doctor service. Complete one of our online consultations and order the medication you need.

You will need to first answer a few short medical questions about your current health and smoking habits. Once the form is completed, you can place an order for Zyban.

Our doctors will review your answers, and if they approve, our pharmacy will dispatch your treatment with your selected delivery method - next-day or nominated-day delivery. Both options are included in the price of the order, as are the consultation and prescription.

If you have any questions or issues while placing your order, feel free to contact Customer Services - their contact information is listed at the bottom of this page.

Note: You must complete a short online consultation so that our doctor can ensure that the treatment is suitable for you. The above pricing should only be used as a reference. The final decision to issue this treatment lies with the prescribing doctor.

Zyban information
Product name Zyban
Active ingredient(s) Bupropion hydrochloride
Manufacturer GlaxoSmithKline (GSK)
Trustpilot rating 5/5
Trustpilot reviews 9
Availability Out of stock
Description Zyban is a norepinephrine/dopamine-reuptake inhibitor (NDRI), designed to help you quit smoking
Exemption Subject to medical prescription
Administration Oral
Presentation Tablets
Available dosage 150 mg(prolonged-release)
Application Adults trying to quit smoking
Usage Consult patient leaflet
Drug class Aminoketone (Antidepressant)
Alcohol consumption N/A
When breastfeeding Not recommended, ask your doctor for alternatives
When pregnant Not recommended, ask your doctor for alternatives
Zyban reviews
Zyban 150mg bupropion hydrochloride prolonged-release 60 tablets Excellent 5 9 patients have reviewed Zyban on Trustpilot

Further reading

What are the effects of smoking?

What are the effects of smoking?

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Does smoking cause erectile dysfunction?

Does smoking cause erectile dysfunction?

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What is the difference between Champix and Zyban?

What is the difference between Champix and Zyban?

Reviewed by Dr. Caroline Fontana
The effects of passive smoking

The effects of passive smoking

Reviewed by Dr. Caroline Fontana
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