How To Get The Best Results With Xenical

What is Xenical and does it actually work?

Xenical (orlistat) is a FDA approved prescription treatment known as 'lipase' inhibitor which works primarily to block the amount of dietary fat absorbed into the body (around 30%). It is available as an oral tablet and is characterised by its dark-blue, hard-gelatin capsules. Each capsule contains 120 mg dose of the active ingredient, orlistat.

A common mistake many make with weight loss treatments such as Xenical is to think that it is an easy and quick way to drop excess weight and look fit and healthy within a few weeks. This common misconception often leads to a lot of wasted time and money, which usually results in high levels of frustration.

If you are overweight or obese and want to lose weight, a treatment like Xenical is prescribed to aid you in achieving your goal. It is not prescribed to get you to your goal on its own. Losing weight requires lifestyle changes if you are serious about it and want your results to last.

Xenical (orlistat) is proven to have a significant effect in reducing the weight of people who use it alongside lifestyle changes, as indicated in the graph below, which shows the average weight loss percentage during clinical trials.

Average weight loss percentage during clinical trials - Xenical vs Placebo
xenical treatment period
Start of treatment
Placebo + diet lead-in period
XENICAL + diet
Placebo + diet

Change in health risk factors as a result of Xenical use

In clinical studies carried out, Xenical 120mg has not just an effect on the weight, but also other positive secondary effects on overall health. a positive effect in reducing the total cholesterol.

Risk Factor Xenical 120 mg Placebo
Metabolic
Total Cholesterol -2.0% +5.0%
LDL-Cholesterol -4.0% +5.0%
HDL-Cholesterol +9.3% +12.8%
LDL/HDL -0.37 -0.20
Triglycerides +1.34% +2.9%
Cardiovascular
Systolic Blood Pressure (mm Hg) -1.01 +0.58
Diastolic Blood Pressure (mm Hg) -1.19 +0.46
Anthropometric
Waist Circumference, cm -6.45 -4.04
Hip Circumference, cm -5.31 -2.96

As shown in the table above, Xenical reduced the total cholesterol percentage in the participants whilst the placebo group experienced an overall increase (which may be deemed normal). A positive outlook was on the decrease of LDL cholesterol ('bad' cholesterol) and an increase of HDL (good) cholesterol in the participants of the study.

As well as the positive effects on the cholesterol in the body, Xenical has also been found to be beneficial in reducing the fasting glucose and insulin as well as marginally reducing the systolic and diastolic blood pressure levels. This could indicate positive results for those who also suffer from type 2 diabetes or high blood pressure. A higher reduction in waist and hip circumference also indicate a reduced risk of associated health complication.

It is already well known and documented, the relationship between obesity and the increased risk of type 2 diabetes. Another study carried out aimed to show that by adding a weight-reducing agent such as Xenical alongside to lifestyle changes, the likelihood of type 2 diabetes would be severely lowered compared to normal weight loss efforts.

The results showed after the 4 years treatment that diabetes occurred in 9.0% of participants treated with the placebo, compared to only 6.2% who were treated with orlistat. Mean weight loss after the 4 years was also greater with orlistat (5.8 vs. 3.0 kg with placebo).

Compared with lifestyle changes alone, Xenical (with lifestyle changes) has been shown to provide a greater reduction in incidence rate for type 2 diabetes as well as greater weight loss. Clearly the beneficial results of using Xenical outweigh its associated adverse effects as shown below.

Year 1 Year 2
Body System/Adverse Event Xenical % Patients Placebo % Patients Xenical % Patients Placebo % Patients
Gastrointestinal System
Abdominal Pain 25.5 21.4 - -
Diarrhoea 5.3 4.4 - -
Gingivitis 4.1 2.9 2.0 1.5
Vomiting 3.8 3.5 - -
Nausea 8.1 7.3 3.6 2.7
Tooth disorder 4.3 3.1 2.9 2.3
Respiratory System
Influenza 39.7 36.2 - -
Ear, Nose and Throat Symptoms 2.0 1.6 - -
Upper respiratory infection 38.1 32.8 26.1 25.8
Lower respiratory infection 7.8 6.6 - -
Skin Problems
Rash 4.3 4.0 - -
Dry Skin 2.1 1.4 - -
Central Nervous System
Dizziness 5.2 5.0 - -
Headache 30.6 27.6 - -
Musculoskeletal System
Back Pain 13.9 12.1 - -
Arthritis 5.4 4.8 - -
Myalgia 4.2 3.3 - -
Tendonitis - - 2.0 1.9

The above table shows the relationship between the duration of Xenical and Placebo use with the adverse effects registered by the participants. From the results provided, it is commonly seen that there is a higher prevalence of side effects in the first year of use compared to the second year. This can be put down to the medical function of prescription treatments. As the body becomes more accustomed to the active ingredient and chemical compounds, adverse effects are less likely to be present.

In the first year of use, the highest recorded adverse effects by the participants were headaches, influenza and abdominal pain. Although this affected between 20-40% of those using Xenical, the differences were marginal compared to those using the placebo. It was clear to see that the treatment only slightly increased the risk of these side effects, but did not stimulate a specific side effect above those experienced by the placebo group.

Year 2 showed a general reduction or absence of many adverse effects, with the highest side effect registered associated with 'upper respiratory infection' (which could be linked to general seasonal changes and other conditions such as asthma). Overall it seems that the medication works well in users and does not pose much of an adverse risk. It is essential though that a doctor is consulted whilst using this treatment to ensure that it is yielding the necessary results.

How can I get the best results?

Xenical is a fat blocker or a lipase inhibitor. It acts to stop fat from your daily calorie intake from being absorbed into the body. This fat is instead passed directly through the body by your normal bowel movements. By eradicating this fat from the body, Xenical aids weight loss.

It is clinically proven to double your chances of losing up to 10% of your body fat when taken together with you making positive lifestyle changes, as proven in the following graph.

The percentage of people using Xenical who lost 5-10% of their bodyweight over a 2 year period

xenical-weightloss-statastics
XENICAL
Placebo + diet

To get the best results however, you will need to:

Follow a healthy, calorie-controlled diet

Xenical is a prescription medicaiton, which means that you cannot buy it without having a consultation with a doctor first.

For the best results using Xenical, you should follow a diet and sensible meal plan. For example, it advised that 30% of your daily intake of calories should be fat. In order for Xenical to prevent all the fat from being absorbed effectively, the consumed fat should be divided equally between your three main meals.

So if you have a daily limit of 1800 calories, 540 calories per day and 180 calories per meal should be fat. The reason for this is that the medication cannot block an entire day's worth of fat with just one dose. Very high fatty foods should therefore be avoided.

Increase your exercise regime

Exercise is a very important aspect not only of losing weight, but also of leading a healthy lifestyle. A fit and healthy body decreases your chance of developing diseases, heart problems and joint conditions. A healthy body is the best weapon when it comes to fighting off diseases. To achieve the best results when taking Xenical, an exercise routine should be followed.

If you already go to gym, walk, jog or do some form of exercise, then you can restructure this routine by increasing the amount you do and setting goals. If you don't do any exercise at all, then find something that you can enjoy so that you will be able to maintain the routine even after you stop taking medication.

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