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Malarone Side Effects

There is a common misconception that the side effects associated with antimalarial treatments are bound to happen and that it's almost not worth taking them. However, side effects are a possibility with any prescription medication and protection against malaria should not be sacrificed on the basis of unfounded myths. Most medications only cause side effects when you start taking them and they tend to subside as your body gets used to them, while many people who take this medication don't get any side effects at all.


Headaches are a common side effect of Malarone, but they are usually mild and do not last for very long. Dizziness is less common but may occur.


Nausea and stomach pains are also common side effects of this antimalarial treatment. This may be accompanied by loss of appetite though this is less common.


It is fairly common for this medication to cause an itchy rash. However, if you experience a severe skin reaction then you must stop taking Malarone and contact a doctor immediately.


Though it is rare, some people taking Malarone experience heart palpitations.

Malarone side effects

Click on the relevant area of the body to find out about how it may be affected by Malarone

Very common Malarone side effects

The most common Malarone side effects are luckily mild and don’t tend to last very long, however if they are persistent or cause you significant discomfort, it might be worth speaking to your doctor. These effects include:

  • Headache
  • Nausea
  • Stomach pains

Common Malarone side effects

The following Malarone side effects are common, which means that they could affect one in ten people that take this treatment:

  • Dizziness
  • Issues sleeping
  • Strange dreams
  • Depression
  • Loss of appetite
  • Itchy rash
  • Fever
  • Cough

Uncommon Malarone side effects

These side effects can occur in one in every 100 people who take Malarone:

  • Heart palpitations
  • Anxiety
  • Swelling in the mouth

Other side effects

Sometimes Malarone can cause severe skin reactions, however they are rare. It's also been noted that people who take Malarone may experience the following effects, however they occur so rarely that the actual frequency is not yet known:

  • Hepatitis
  • Inflammation of the blood vessels
  • Peeling skin
  • Blisters
  • Increased sensitivity to sunlight
  • Panic attacks
  • Crying
  • Mouth ulcers
  • Seizures
  • Nightmares

Severe reactions to Malarone

The most severe side effects can occur after an allergic reaction to the active ingredients in Malarone, Atovaquone and Proguanil, which is why this treatment should not be taken if you are aware of an allergy to any of these ingredients. If you take this treatment and you experience any Malarone side effects such sudden difficulty breathing, skin rash, swelling of the face or any other part of the body, you should seek medical help straight away.

Who shouldn't take Malarone?

There are some people that are more likely to experience Malarone side effects than others and should avoid taking this treatment at all. These people include those who are allergic to the active ingredients in Malarone and people with severe kidney problems. Malarone is also best avoided by pregnant women.

There might also be instances where the risk of developing Malarone side effects is moderate and you may simply need to take an adjusted dose or take care while taking it, so make sure that you mention any medical conditions you may have during your online consultation.

Malarone and other medications

It’s possible for people who are taking certain types of medication to be more likely to experience Malarone side effects. The working of these medications might also be affected by taking Malarone and could include etoposide (cancer treatment), metoclopramide, certain antibiotics and warfarin.

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